Patent Ductus Arteriosus (PDA) (Management and Controversy)

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Physiology and PathophysiologyFetal life Ductus open R→L shuntPostnatal Transitional Period Ductus opening R←→L shunt Bidirectional shuntRegulation of Ductus Patency in Fetal Life Dilating factors: Increasing vascular pressure within the ductus, opposing ductus constriction Vasodilators—circulating PGE2., PGs and Nitric Oxide (NO) from ductus, CO from endothelial and muscle cell of the ductus.Contracting Factors Extracellular Calcium Endothelin-1
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