Nuclear factor kappa-beta (NF-κB) is a critical transcription factor responsible for modulating the expression of many genes involved in the pathogenesis of psoriasis.SUMO4 is a negative regulator of NF-κB in the process of cell signaling transduction.Two functional single nucleotide polymorphisms (SNP),-94ins/delATTG in NFKB 1 gene and the rs237025 A>G in SUMO4 gene, had been found to be the risk of some autoimmune diseases.Whereas their correlation with the susceptibility of psoriasis vulgaris, a newly-defined autoimmune-related disease, remained unknown now.So we genotyped the two polymorphisms in 519 patients with psoriasis vulgaris and 541 healthy controls.We found that the ins/ins genotype frequency in NFKB1 were significant differences among the psoriasis cases and the controls (x2test P=0.018).By stratified analysis, the frequency of the ins/ins genotype was statistically higher among the patients of onset age≤<40, PASI>20, male patients and sporadic patients than among controls.While no statistically significant association has been found between the rs237025 A>G polymorphism in SUMO4 gene and the susceptibility of psoriasis vulgaris even stratified analysis by the age of onset, family history, PASI score and gender.