Angiogenesis is an essential part of wound healing and angiogenesis impair may result in the occurrence of chronic ulcer.Sympathetic nervous system plays an important role on angiogenesis.It plays its biologic role primarily through the interaction between neurotransmitters released from nerve terminals and receptors in target organs.Among this, the activation or inhibition of adrenergic receptors (primarily β -adrenergic receptor) affects angiogenesis most.In addition, sympathetic nerves locate near pericytes of microvascular, go along the capillaries and there are adrenergic receptors on the surface of endothelial cells and pericytes.As a result, sympathetic nerve may participate in angiogenesis by influencing endothelial cells and pericytes of new capillaries.