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Glucokinase catalyzes the phosphorylation of glucose in liver and pancreatic b-cells.In vitro studies and murine genetic models demonstrated that the activity of glucokinase exhibits a high flux control coefficient for hepatic glucose utilization and also determines the glucose threshold for insulin secretion by β-cells.In humans inactivating mutations within gck, the glucokinase-encoding gene, are associated with maturity onset diabetes of the young (MODY) 2.