Objective: To explore the Effects of early goal directed therapy(EGDT) in septic shock.Methods: A total of 148 septic shock patients were divided into two groups randomly: the treatment group (apply early goal directed therapy) for 73 patients and the control group (apply Conventional treatment) for 75 patients,the mortality of 30d、60d were compared between the two groups.Results: there is no significant differences between the treatment group than that the control group in the mortality of 30d、 60d (P=0.623,P=0.812);The mean intravenous fluid volume was significantly lower in the control group than that in treatment group during the first 6 hours (P=0.013);there is no significant differences between the two groups in duration of intensive care unit(ICU)stay (P=0.675) 、 in hospital stay (P=0.729);there is no significant differences between the two groups in new organ failure of renal、 respiratory、cardiovascular (P=0.722,P=0.763,P=0.524);There was no significant difference between the two groups in the use of vasopressors (P=0.773),in the use of renal replacement therapy(P =0.722),in the use of mechanical ventilation(P =0.794);there is no significant differences between the two groups in gender、 Age、 APACHE Tr scoer、 Charlson comorbidity score、 Positive blood culture (all P > 0.05).Conclusions: early goal directed therapy(EGDT) in septic shock did not improve outcomes.