2. 您的位置
3. 首页
4. 会议论文
5. Hrd1 facilitates tau degradation by proteasome and lysosome pathways

Hrd1 facilitates tau degradation by proteasome and lysosome pathways

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：xxxx000456

【摘 要】

：

Intraneuronal accumulation of abnormal phosphorylated tau (p-tau) is a molecular pathology in many neurodegenerative tauopathies, including Alzheimers disease (AD), Progressive supranuclear palsy and

【作 者】

：

Li FENG An SUN N ZHU Q LI S FANG YX SHEN 

【机 构】

：

Biopharmaceutical Research Institute,, Anhui Medical University, Hefei 230032, China;School of Basic

【出 处】

：

The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

：

2013年4期

【关键词】

：

Alzheimer's disease tau tauopathies Hrd1 ubiquitin-proteasome pathway autop 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Intraneuronal accumulation of abnormal phosphorylated tau (p-tau) is a molecular pathology in many neurodegenerative tauopathies, including Alzheimers disease (AD), Progressive supranuclear palsy and frontotemporal dementia with parkinsonism-linked to chromosome 17 (FTDP-17).

其他文献

Xanthotoxol suppresses the inflammatory response and protects against ischemic brain injury followin

Aim: Our previous study has demonstrated that xanthotoxol possesses neuroprotective properties following transient focal cerebral ischemia.The present study was designed to investigate the effect of x

会议

xanthotoxolpermanent focal cerebral ischemiainflammatory response

Effects of xanthoceraside on memory impairments and central cholinergic system in rats by lesions of

Aim: The present study is to investigate the effect and mechanisms of xanthoceraside on memory impairments and central cholinergic system in Alzheimers disease (AD) rat model conducted by lesions of b

会议

xanthocerasideAlzheimer's diseaselearning and memoryMeynert's basal

Determination of lapachol by liquid chromatographic-mass spectrometry and the application to pharmac

Aim: To study the quantification methods and pharmacokinetic application of lapachol.Methods: A sensitive and specific high-performance liquid chromatography-tandem mass spectrometry method (LC/ESI/MS

会议

lapacholdeterminationpharmacokineticsLC-ESI-MSn

Telomere-independent Rap1, modulates NF-κB-dependent inflammation in macrophages

Aim: The activity of nuclear factor (NF-κB) is modulated by cytoplasmic repressor activator protein 1 (Rap1) in cancel cells.Experiments were designed to test whether or not Rap1 is present in atherom

会议

Rap1NF-κBmacrophageinflammationatherosclerosis

Aquaporin-1 dependent proximal tubular cells migration mediates reno-protective effect of acetazolam

Aim: The study is to investigate whether diuretic acetazolamide (AZA) protects against renal ischemia-reperfusion (I/R) injury, and its possible link with water channel aquaporin-1 (AQP1).Methods: In

会议

Aquaporin-1 (AQP1)ischemia-reperfusionacute kidney injuryacetazolamidemigrat

WS070117 ameliorates the formation of foam cells by regulating the expression of LOX-1 and ABCG1 in

Aim: The present study investigated the effects of WS070117, a novel small molecule compound, on foam cell formation, and the possible underlying mechanism.Methods: J774.A1 murine macrophages were pre

会议

WS070117foam cellsLOX-1ABCG1AMPK

Thymoquinone causes endothelium-dependent augmentation depending on activation of soluble guanylyl c

Aim: Experiments were designed to determine the effects of thymoquinone, an alkaloid with vasodilator properties, in coronary arteries.Methods: Rings, with or without endothelium, of porcine coronary

会议

8-Bromo cyclic GMPdeta NONOatehypoxianitric oxideprostaglandin F2α

4-HNE increases intracellular ADMA levels in cultured HUVECs through miR-21-dependent mechanisms

Aim: To investigate whether 4-hydroxynonenal (4-HNE) regulates asymmetric dimethylarginine (ADMA) metabolism through affecting the expression of ADMA metabolizing enzymes and the involvement of microR

会议

microRNA 21 (miR-21)dimethylarginine dimethylaminohydrases (DDAH)asymmetric di

Therapeutic effects of ginsenoside metabolite compound K in adjuvant-induced arthritis via attenuati

Aim: An in vitro study has shown joint-protective effects of ginsenoside metabolite compound K (CK) in RA, but the effects of CK in RA animal model and the mechanisms are still unknown.In this study,

会议

ginsenoside metabolite compound Kdendritic cellsadjuvant-induced arthritisimm

Penetration of verapamil across blood brain barrier following cerebral ischemia depending on both pa

Aim: Blood brain barrier (BBB) dysfunction is a common facet of cerebral ischemia, and the alteration of drug transporter, P-glycoprotein (P-gp), has been documented.This study explores influence of d

会议

cerebral ischemiablood brain barrierP-glycoproteinverapamil