【摘 要】
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Hepcidin is an antimicrobial peptide,which also negatively regulates iron in circulation by controlling iron absorption from dietary sources and iron release fr
【机 构】
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SchoolofBiomedicalSciences,TheChineseUniversityofHongKong,HongKong
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Hepcidin is an antimicrobial peptide,which also negatively regulates iron in circulation by controlling iron absorption from dietary sources and iron release from macrophages.Hepcidin is synthesized mainly in the liver,where hepcidin is regulated by iron loading,inflammation and hypoxia.Genetic studies have identified three membrane-associated proteins,i.e.,HFE,TfR2 and HJV are critical upstream regulators of hepcidin expression.Recently,we have demonstrated that bone morphogenetic protein (BMP)-hemojuvelin (HJV)-SMAD signaling is central for hepcidin regulation in hepatocytes.However,the molecular mechanisms by which HFE regulates hepcidin expression in the liver remain to be elucidated.
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