Deficiency of spicing factor SF3B1 affects human erythropoiesis in a stage-specific manner

来源 :The 2nd International Symposium on Erythrocyte Biology(2016第 | 被引量 : 0次 | 上传用户：ghchao0605

【摘要】

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【作者】

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Yumin Huang John Hale Lixiang Chen Xinhua Guo Huizhi Zhao Narla Mohandas Ling Sun Xiuli An

【机构】

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Department of Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou,Henan 450

【出处】

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The 2nd International Symposium on Erythrocyte Biology(2016第

【发表日期】

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2016年10期

【关键词】

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Erythropoiesis MDS RARS SF3B1 RNA-seq

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　　Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell heterogeneous disorders characterized by dysplasia of bone marrow cells and cytopenia of peripheral blood.Refractory anemia with ring sideroblasts (RARS) is a subtype of MDS and constitutes about 3-11% of all MDS cases.

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Deficiency of spicing factor SF3B1 affects human erythropoiesis in a stage-specific manner

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