GABA transporter-1 inhibitor NO-711 alters the EEG power spectra and increases non-rapid eye movemen

来源 :中国睡眠研究会第7届全国学术年会暨2012金陵国际睡眠医学论坛 | 被引量 : 0次 | 上传用户：cs19890126

【摘要】

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【出处】

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中国睡眠研究会第7届全国学术年会暨2012金陵国际睡眠医学论坛

【发表日期】

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2012年8期

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　　GABA transporter subtype 1 (GAT1) constructs high affinity reuptake sites for GABA in the CNS and regulates GABAergic transmission.Compounds that inhibit GAT1 are targets for epilepsy treatment.Sedation has been reported as a side effect of these agents, indicating possible sedative or hypnotic potential.To elucidate the role of GAT1 in sleep-wake regulation, we observed the sleep behaviors of mice treated by NO-711, a selective GAT1 inhibitor.

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GABA transporter-1 inhibitor NO-711 alters the EEG power spectra and increases non-rapid eye movemen

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