Reaction Pathway and Free Energy Profile for Acetylcholine Hydrolysis Catalyzed by Human Butyrylchol

来源 :International Conference on Theoretical and High Performance | 被引量 : 0次 | 上传用户：moete

【摘要】

：

　　The A199S/F227A/S287G/A328W/Y332G mutant of human butyrylcholineserase (BChE) catalyzes the hydrolysis of cocaine with high efficiency.It is not clear wheth

【作者】

：

XiChen[1]WenchaoYang[1]JunjunLiu[1]LeiFang[2]Chang-GuoZhan[2]

【机构】

：

College of Chemistry and Material Science, South Central University for Nationality Wuhan 430074, P.

【出处】

：

International Conference on Theoretical and High Performance

【发表日期】

：

2013年期

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　　The A199S/F227A/S287G/A328W/Y332G mutant of human butyrylcholineserase (BChE) catalyzes the hydrolysis of cocaine with high efficiency.It is not clear whether or not this hydrolyase will enhance the hydrolysis of neurotransmitter acetylcholine (ACh), which is an important neurotransmitter in the impulse transmission.

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Reaction Pathway and Free Energy Profile for Acetylcholine Hydrolysis Catalyzed by Human Butyrylchol

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