【摘 要】
：
The extracellular concentration of adenosine increases in the cortex and basal forebrain during prolonged wakefulness and decreases during the sleep recover
【出 处】
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中国睡眠研究会第7届全国学术年会暨2012金陵国际睡眠医学论坛
论文部分内容阅读
The extracellular concentration of adenosine increases in the cortex and basal forebrain during prolonged wakefulness and decreases during the sleep recovery period.Therefore, adenosine is proposed to act as a homeostatic regulator of sleep and to be a link between the hormoral and neural mechanisms of sleep-wake regulation.There are four subtypes of G protein-coupled adenosine receptors, A1, A2A, A2B and A3, expressed in the CNS.Our previous findings showed that the A2AR plays a predominant role in the induction of sleep.
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