<正>CaMKKa and CaMKKp are highly homologous（65%identical） Ser/Thr-directed kinases activated in response to a rise in intracel- lular Ca²⁺.Whereas both enzymes phosphorylate and activate CaMKI and CaMKIV,only CaMKKp forms a complex with and activates AMPK.However,even though both CaMKKs activate CaMKI and CaMKIV similarly,there are important differences in how the two CaMKKs are regulated.First,CaMKKa can be phosphorylated by protein kinase A（PKA） leading to the recruitment of 14-3-3 and inactivation of the enzyme.Although some of these PKA sites are conserved in CaMKKβwe find that CaMKKp is