Maropitant a neurokinin-1(NK-1) receptor antagonist used as an antiemetic drug in dogs by blockade of substance P/NK-1 receptor binding in the vomiting center and chemoreceptor trigger zone in the central nervous system.In addition,substance P and NK-1 receptors have been isolated in nociceptive pathways.Therefore,it is expected that maropitant provides analgesic effect and its sparing effect of minimum alveolar concentration(MAC) has been reported in dogs.The purpose of this study was to evaluate the sparing effect of an approved antiemetic dose of maropitant on the MAC for blunting adrenergic response(MAC-BAR) of sevoflurane in dogs.