GABAergic inputs at the axon initial segment yield timing-dependent bidirectional effects in the int

来源 :The 6th FAONS Congress and 11th Biennial Conference of CNS(第 | 被引量 : 0次 | 上传用户：guojicai

【摘要】

：

【作者】

：

Nan Liu Xiaohui Zhang

【机构】

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State Key Laboratory of Cognitive Neuroscience and Learning,IDG/McGovern Institute for Brain Researc

【出处】

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The 6th FAONS Congress and 11th Biennial Conference of CNS(第

【发表日期】

：

2015年3期

【关键词】

：

chandelier cell GABA excitation shunting inhibition nonlinear integration axonal

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　　GABAergic synaptic inputs derived from chandelier cells locate exclusively at the axon initial segment(AIS)of pyramidal cells(PCs).Experimental evidences showed that these GABAergic inputs elicit depolarizing membrane potential changes from resting state,and induce both excitatory and inhibitory impacts on the activity of postsynaptic PCs with an dependence of the ongoing membrane potential levels.

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GABAergic inputs at the axon initial segment yield timing-dependent bidirectional effects in the int

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