【摘 要】
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Objective To investigate the neuroprotective potential of rhEPO in premature rats with white matter damage.Methods Pregnant rats (gestational age 15 days) were intraperitoneal-injected of LPS (300 g/k
【机 构】
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The Affiliated Hospital of Qingdao University
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Objective To investigate the neuroprotective potential of rhEPO in premature rats with white matter damage.Methods Pregnant rats (gestational age 15 days) were intraperitoneal-injected of LPS (300 g/kg) to make cerebral white matter lesions.Another 10 cases of pregnant rats were intraperitoneal injectioned with saline (1ml/kg) as control.All preterm rats born by caesarean section at embryonic day 21st.According to the different processing method, the preterm rats were randomly divided into LPS+rhEPO group (n=18), LPS+NS group (n=18), NS+rhEPO group (n=18) and NS+NS group (n=18) and were respectively intraperitoneal injected of rhEPO (5000IU/kg) or saline 1ml/kg immediately after birth.The cerebral white matter injury were evaluated with HE and levels of CD68, GFAP, MBP were detected with immunofluorescence 3 and 7 days after birth.Assessments of nerve behavior were taken 2 weeks after birth.
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