Degenerative diseases of nervous system are very commonly occurred in modem society.To understand the mechanism from basic researches on how these diseases happened is critically important for drug development and clinical treatment.To address this issue,I wish to take a look on the view point from functional genomics to drug discovery.The balance between energy formation and energy consumption in the neuronal cells will be discussed at first from recently discovered neuroprotective molecular network pathway based on the study of an oxygen-binding protein family including neuron-specific neuroglobin,extensively expressed cytoglobin and eye-specific globin.The mechanism on neuroprotective function of neuroglobin will be introduced based on our study.