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目的观察不同剂量辛伐他汀对急性脑梗死患者的血脂、血清炎性因子(超敏C-反应蛋白(hs-CRP)和肿瘤坏死因子-α(TNF-α))的影响。方法将泸州医学院附属中医院急性脑梗死患者随机分为辛伐他汀常规治疗组、辛伐他汀强化降脂组和对照组各36例,辛伐他汀常规组治疗组予以脑梗死基础治疗+辛伐他汀10 mg,每晚1次;辛伐他汀强化降脂组予以脑梗死基础治疗+辛伐他汀40 mg,每晚1次;对照组予以脑梗死基础治疗+安慰剂10 mg,每晚1次,治疗前后检测患者的血脂、CRP、TNF-α。结果强化降脂组及常规组中血清血脂及CRP、TNF-α水平均明显低于对照组(P<0.01),而且强化降脂组中血清血脂及CRP、TNF-α水平均低于常规组(P<0.01),三组差异均有统计学意义。结论急性脑梗死强化降脂治疗更能降低血清血脂及CRP、TNF-α水平,有利于疾病康复。
Objective To observe the effects of different doses of simvastatin on serum lipids, serum inflammatory cytokines (hs-CRP) and tumor necrosis factor-α (TNF-α) in patients with acute cerebral infarction. Methods Patients with acute cerebral infarction of TCM Hospital Affiliated to Luzhou Medical College were randomly divided into simvastatin treatment group, simvastatin intensive lipid lowering group and control group, 36 cases each. The simvastatin treatment group was given basic treatment of cerebral infarction + Simvastatin intensive lipid-lowering group was given basic treatment of cerebral infarction + simvastatin 40 mg, night 1; the control group was given basic treatment of cerebral infarction + placebo 10 mg, night 1 Second, before and after treatment in patients with serum lipids, CRP, TNF-α. Results The levels of serum lipids, CRP and TNF-α in intensive lipid-lowering group and conventional group were significantly lower than those in control group (P <0.01), and the levels of serum lipids, CRP and TNF-α in intensive lipid-lowering group were lower than those in control group (P <0.01), the differences between the three groups were statistically significant. Conclusion Intensive lipid-lowering treatment of acute cerebral infarction can reduce serum lipids, CRP and TNF-α levels, which is beneficial to the recovery of the disease.