Public concerns on the risk of genetically modified (GM) crops to the health of mammals including human calls for robust risk assessment.In the present study, we conducted a 90-day feeding trial with GM soybean suspension in Japanese quails.The animals were by gavage fed daily on either the GM soybean (XKD0101) expressing the CP4-EPSPS protein which confers high glyphosate tolerance or the parental non-GM soybean variety (XD9) while a third group of the animals was provided a commercial basal diet containing GM-free soybean.No adverse effect on clinical behavior or body weight was observed.The comparative toxicological examination of dissected tissues and blood samples showed, with few exceptions, no significant histological and biochemical effects during the 90-day exposure among the three groups.No sex or dose effects on the parameters examined were observed.Furthermore, another 14d recovery period did not influence those examined toxicological parameters.The results were consistent with most previous studies, indicating that a dose as high as 2 g kg-1 d-1 of glyphosate-tolerant soybean would not cause adverse effects on Japanese quails in prolonged exposure (90-d).Based on a literature survey on the GM crops feeding trails targeted different foreign genes, we found that daily doses might define GM crops exposure and provide a link between exposure and potential risk.To conclude, our present study showed that GM soybean(XKD 0101) is as safe as its unmodified counterpart (XD 9) to Japanese quails.