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Objective: Trichosanthes pericarpium injection is widely used to cure coronary heart disease, myocardial ischemia patients in China.In previous studies, we find that t.pericarpium injection could significantly reduce the myocardial infarction rate and the serum activity of creatine-kinase (CK) et al in acute myocardial ischemia model rats.This study was designed to find out the mechanism underlying this pharmacodynamical protective effect.