论文部分内容阅读
Synthesis,biological evaluation,docking and dynamicsstudies of furan-based peptides as 20S proteasom
【机 构】
:
Department of Medicinal Chemistry,School of Pharmaceutical Sciences,Peking University Health Science
【出 处】
:
全国药物化学学术会议暨第四届中英药物化学学术会议
【发表日期】
:
2013年11期
其他文献
One-pot synthesis of 4-methylisoquinolines via sequential Pd-catalyzed Heck reaction and intramolecu
An efficient,one-pot synthesis of 4-methylisoquinolines via a cascade Pd-catalyzed Heck reaction,intramolecular cyclization and isomerization has been developed.
Design,synthesis and preliminary anti-fibrotic activity study of 1,6-disubstituted-2(1H)-pyridone co
Idiopathic pulmonary fibrosis(IPF)is commonly considered the result of a recurrent injury to the alveolar epithelium followed by an uncontrolled proliferation of fibroblasts.Currently,there is no effi
Salification is most commonly employed for modifying physical and chemical properties.However,there are few reports about the differences in biological activity between different salt forms and free a
肿瘤多药耐药(MDR)是指肿瘤细胞对一种药物出现耐药性后,对其他化学结构和作用机制不同的药物产生交叉耐药性[1]。肿瘤的多药耐药形成机制有多种,其中研究最深入也是最重要的一种机制为ABC(ATP-Binding Cassette)超家族膜蛋白介导的药物外排泵的过表达。
目的 阿尔茨海默症(AD)是一种复杂的中枢神经系统退行性疾病,目前全球患者已超过3600万。临床上用于治疗AD的药物只有5个,均属于单靶点抑制剂。这类药物只能缓解AD 的症状,不能从根本上改善疾病状态或终止疾病进程。
Title-Improvement of pharmacokinetics behavior of apocynin by nitrone derivatization:Comparative pha
Apocynin,a potent inhibitor of NADPH-oxidase,was widely studied for activities in diseases such as inflammation-mediated disorders,asthma and cardiovascular diseases.
Near-infrared fluorescent dyes have widely used as fluorescence probes,due to their maximum absorption peak is greater than 700nm where a biological matrix exhibits the least absorption and autofluore
The Ras/Raf/MEK/ERK pathway(ERK pathway)is a member of the four distinct mitogen-activated protein kinase(MAPK)signaling pathways,which play critical roles in regulation of diverse cellular activities
会议