Electrochemically Synthesis of 3-Azido-lndolines byAmino-Azidation of Alkenes

来源 :中国化学会第十六届全国有机合成化学学术研讨会 | 被引量 : 0次 | 上传用户:ycmk07js2
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Organic azides have been demonstrated as important molecules not only due to their remarkable biological activities.thus widely incorporated into lead compound design in drug discovery,1 but also due to their synthetic versatility,as powerful precursors for a great number of nitrogen-containing species.
其他文献
Pyrimidin-2(1H)-ones as one of important organic compounds could be found in nature products,pharmaceutical intermediates and chemical building blocks.1 Up to now,the two-step synthetic method combini
2-吲哚酮是一类特殊的杂环化合物骨架,普遍存在于天然产物和药物骨架中,也是药物设计和有机合成的重要前体1.在过去几十年中,研究工作者们已开发出一系列构建2-吲哚酮骨架化合物的有效方法.
Pyrroles are one of the most prevalent heterocyclic compounds,and are widely present as the basic cores in many natural products,potent pharmaceutical compounds,and a variety of functional materials.
Aryl nitriles are important structural motifs present in various therapeutically significant natural products and marketed drugs.[1] Moreover,nitriles can be easily transformed to a series of function
1苯并呋喃类衍生物广泛的存在于天然产物当中,并具有多种良好的生物活性。天然产物中呋喃类化合物的提取与分离困难,产率低,很大程度上阻碍了其生物活性等方面的研究。
生物柴油作为传统柴油的替代性可再生生物能源,在欧美国家已大规模使用。目前广泛使用的生物柴油传统制备方法耗能大、成本高,作为新兴技术的原位转酯化方法近年来受到国内外学者的广泛关注,已成为生物柴油有机合成领域的研究热点。
手性 3-取代-3-羟基-2-氧化吲哚作为一种重要的骨架结构单元广泛的存在于天然产物和药物分子中1.2010年,A.K.Franz小组2报道了由手性钪(Ⅲ)-吡啶双恶唑啉复合物催化的5-溴-N-甲基靛红与烯醇硅化物的对映选择性Mukaiyama Aldol反应,以高的产率和对映选择性得到目标产物.
含磷杂环化合物是一类具有广泛生物活性的重要有机化合物。[1]近年来,六元环状烯醇磷酸酯因其在酶抑制剂方面的作用而备受关注。[2]而目前其合成方法有限,多需通过过渡金属催化的预官能团化实现,普遍存在原料不易得,步骤繁琐,底物受限等问题。
Many organic molecules containing oxindole backbone exist in natural products and small drug molecules1.The isatin-derived β,γ-unsaturated α-keto ester,it can be used as a starting material to react w
Water,as a safe,inexpensive and environmentally benign reaction medium,has been included as the notion of “green chemistry”.However,the insolubility of many organic compounds in water severely limited