Direct observation and ligand regulation of oligomeric state of CXCR4-EGFP on the membrane of living

来源 :中国化学会生物物理化学专业委员会第四届全国生物物理化学会议 | 被引量 : 0次 | 上传用户:wanyu123456
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  Dimmerization or even higher order of oligomerization is a key feature of many G protein coupled receptors(GPCRs),which regulates the functions of GPCRs and provides a unique scenario for the rational design of new therapeutic drugs.However,it is still difficult to characterize the oligomeric status of GPCRs in living cells and not yet clear how binding ligands regulate this status.
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