Lipid mediators derived from metabolism of polyunsaturated fatty acids (PUFAs) play an important role in various human physiological and pathophysiological processes.Prostaglandins, leukotrienes, and hydroxyeicosatetraenoic acids (HETEs) are derived from oxidative metabolism of arachidonic acid by cyclooxygenases (COXs), lipoxygenases (LOXs), and cytochrome P450 enzymes.