【摘 要】
：
Objective Silicon nanoparticles (SNPs) are applicable in various fields due to their unique physicochemical characteristics.However,concerns over their potential adverse effects have been raised.In ou
【机 构】
：
School of Public Health,Capital Medical University,Beijing,100069,P.R.China;Beijing Key Laboratory o
论文部分内容阅读
Objective Silicon nanoparticles (SNPs) are applicable in various fields due to their unique physicochemical characteristics.However,concerns over their potential adverse effects have been raised.In our previous studies,we reported that SNPs could induce abnormal high incidence of multinucleation.In this study,we further investigated the mechanisms of multinucleation induced by SNPs in human normal liver L-02 cells (L-02 cells).
其他文献
目的 比较两种荧光波长CdSeS/ZnS-COOH合金量子点对染色体的损伤,为揭示纳米材料遗传毒作用特征积累资料、提供依据.方法 采用L5178Y细胞胞质分裂阻滞微核细胞组学试验(CBMNt)作为研究系统, 以490nm和540nm两种荧光波长的合金量子点CdSeS/ZnS-COOH为受试物,终浓度均为0.0625mg/ml,0.125mg/ml,0.25mg/ml,0.5mg/ml,0.1mg/
Objective To investigate the molecular mechanism of endosulfan reproductive toxicity.Methods The GC-lspg cells were exposed to 0,6,12 and 24μg/mL endosulfan for 24h,respectively.Cell viability was det
目的 观察某公司生产的两种功能袋泡茶对人源多器官细胞增殖的影响.方法 应用多器官人源细胞系共培养模型,在同样受试物暴露浓度和条件下通过细胞形态变化和MTT比色法,观察对A549、HepG-2、HEK-293、SH-SY5Y和CCC-HEH-2五种细胞的影响,减肥茶和常润茶受试浓度0.39、0.78、1.56、3.12和6.25 mg/mL,作用24h后.
Objective:Although the involvement of endosulfan in several areas of blood toxicity is now clearly established,its role in vascular dysfunction at the endothelial level remains to be elucidated.In thi
Objective The purpose of this work was to investigate the blood toxicity of different doses of endosulfan in Wistar rats.Methods The experimental sample was composed of four groups,a control group tha
目的：纳米二氧化钛(Nano-TiO2)作为一种新型光催化剂、抗紫外剂和光电效应剂而被广泛应用，近来研究表明Nano-TiO2作用于小鼠可导致氧化性的DNA损伤，但其中所涉及的分子机制至今尚不明朗。本研究通过观察二氧化钛导致DNA损伤、影响抗氧化酶活性诱导脂质过氧化物的产生等，探讨纳米二氧化钛对小鼠的毒性作用，并用不同剂量的葡萄籽预处理纳米二氧化钛染毒小鼠，探讨葡萄籽对纳米二氧化钛所致DNA损伤的
Objective:To determine whether chemicals full exposure during the period of sexual maturity and reproduction induce toxicity effect in reproduction,we performed brood size assay under 7-days chemical
目的 毒死蜱(Chlorpyrifos,CPF)是我国推荐使用的低毒有机磷农药,其大量应用对环境造成持续污染,而儿童比成年人有更多的暴露机会和更高的生物易感性,可产生更为严重的神经毒性作用.本研究通过对幼龄大鼠重复染毒,探讨CPF的神经发育毒性.方法 对新生雄性大鼠施以连续灌胃染毒(PNDl-21),染毒剂量为不引起动物出现明显有机磷中毒症状的低剂量(0.3、1、3mg/kg),溶剂对照组给予同溶
Objective To observe the mechanisms of the abnormal expression of miR34a and miR133a induced by the anatase titanium dioxide nanoparticles(TNPs 25nm).Methods AHH-1 cells were treated with the anatase
Objective To study the regulating mechanisms of the anatase titanium dioxide nanoparticles(TNPs)-induced cell toxicity.Methods A549 cells were treated with the anatase titanium dioxide nanoparticles f