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More than 50 % of patients with low-and high-grade gliomas suffer from seizures, and treatment includes both antitumor directed measures as well as administration of anti-epileptic drugs (AEDs).Apart from tumor removal, surgery will usually also produce an effective seizure response.Cranial radiotherapy may lead to a decrease in seizure frequency of > 75 %, and administering temozolomide (TMZ) reduces seizures in more than 50 % of patients with low-grade gliomas.