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Nesfatin-1 is an anorexigenic brain-gut peptide discovered in 2006.The previous studies about nesfatin-1 focused on hypothalamus and brainstem circuits which implicated in feeding regulation.Recently,nesfatin-1 was reported to be also expressed in the nucleus accumbens (NAc),lateral parabrachial nucleus and amygdaloid nucleus of mice,which were related to the control of rewarding behavior.