【摘 要】
：
Background We aimed to investigate the relationship between cytochrome (CYP) 2C19 *2,*3 polymorphisms and high on-treatment platelet reactivity (HPR) in patients treated with percutaneous coronary int
【机 构】
：
First Affiliated Hospital of Soochow University,Jangsu,China
【出 处】
：
第十二届中国介入心脏病学大会(CIT2014)
论文部分内容阅读
Background We aimed to investigate the relationship between cytochrome (CYP) 2C19 *2,*3 polymorphisms and high on-treatment platelet reactivity (HPR) in patients treated with percutaneous coronary interventions (PCI) and dual antiplatelet therapy over a 6-month period.Totally 47 patients post-PCI were enrolled in the first affiliated hospital of SooChow university from June 2012 to September 2012.Patients received a 300 mg loading dose (LD) clopidogrel and aspirin or 75 mg/d clopidogrel and 100 mg/d aspirin maintenance dose (MD) before PCI,then continued with clopidogrel and aspirin MD as dual antiplatelet therapy.Max platelet aggregation (MPA) was assessed by light transmittance aggregometry (LTA) following 2 μmol/L and 5 μrmol/L adenosine diphosphate (ADP) stimili in post-PCI patients after 6 months.Direct sequence was used to genotype the CYP2C19*2,CYP2C19*3 polymorphisms in these patients.HPR was defined as MPA ≥46％,whereas those having ＜46％ were nHPR.Basic clinical data,routine examination,PCI details,MPA and CYP2C19 polymorphisms were assessed and compared between HPR group and nHPR group.According to CYP2C 19 polymorphism,we examined MPA and HPR in different phenotype.
其他文献
Background Some data has challenged the concept that high-density lipoprotein (HDL) cholesterol (HDL-C) was inversely associated with cardiovascular risk,and suggested apolipoprotein A-I (apoA-I) or H
Background To test serum macrophage migration inhibitory factor (MIF) and investigate the correlation between different types of angina with coronary heart disease (CHD) patients and coronary artery s
Background Percuataneous coronary intervention (PCI) is an important method to reconstruct vessels in patients with coronary heart disease,and vascular restenosis can be significantly reduced.In order
Background To compare the characterization of coronary atherosclerotic plaques in patients with unstable angina pectoris (UAP) and stable angina pectoris (SAP) by optical coherence tomography (OCT).Me
Background TMP an alkaloid extracted from Ligusricum wallichii Franchat (Apiaceae),has been widely used in traditional Chinese medicine for the treatment of cardiovascular and neurovascular diseases.O
Background This study aimed to compare the detection rate of coronary heart disease between different gender,compare the severity of coronary artery disease of male and female patients,compare gender
Background To investigate the protective effect of alprostadil for coronary heart disease patients with type 2 diabetes on contrast medium-induced nephropathy (CIN) after percutaneous coronary interve
Background To explore the relationship between apolipoprotein E (ApoE) gene polymorphism and coronary heart disease,and the influence ofApoE gene polymorphism on the atorvastatin lipid-lowering effect
Background To assess left ventricular systolic and diastolic function and wall motion synchronism in patients with acute myocardial infarction using real-time three-dimensional echocardiography,evalua
Background Circulating progenitor/stem cells provide an endogenous repair mechanism of the dysfunctional endothelium from percutaneous coronary intervention (PCI),which may play an important role in t