New mechanisms of metastatic bone cancer pain:Cancer tissue-derived endogenous formaldehyde activati

来源 :The 6th FAONS Congress and 11th Biennial Conference of CNS(第 | 被引量 : 0次 | 上传用户：bambooasu

【摘要】

：

【作者】

：

TONG Zhi-Qian LI Yan LIU Jia LIU Feng-Yu HAN Ying WAN You

【机构】

：

Neuroscience Research Institute,Peking University,Beijing 100191;Laboratory of Brain Disorders,Minis

【出处】

：

The 6th FAONS Congress and 11th Biennial Conference of CNS(第

【发表日期】

：

2015年3期

【关键词】

：

bone cancer pain formaldehyde transient receptor potential vanilloid subfamily m

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　　In recent years,our serial investigations focused on the role of cancer cells-derived endogenous formaldehyde in bone cancer pain.We found that cancer cells produced formaldehyde through demethylation by serine hydroxymethyltransferase(SHMT1 and SHMT2)and lysine-specific histone demethylase 1(LSD1).

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New mechanisms of metastatic bone cancer pain:Cancer tissue-derived endogenous formaldehyde activati

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