A newly developed class of quinoline-based chiral biphosphine ligand,6,6-bis(diphenylphosphino)-5,5-biquinoline(BIQAP) was synthesized via a simple two-step reactions using optically pure BIQOL as starting material and the stereochemical structure of(R)-BIQAP was determined by X-ray crystallography.The combination of the readily available chiral biphosphine ligand BIQAP with [Ir(COD)Cl]2 in THF resulted in a highly effcient catalyst system for asymmetric hydrogenation of quinolines at quite low catalyst loadings(0.05-0.002 mol ％),affording the corresponding product in good yields and high enantioselectives(up to 91 ％).