OBJECTIVE In this study,we used a new cationic peptide H3R5 as a reducible vector,aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe,miRNA-195(miR195)as a powerful gene drug to inhibit VEGF,and Fasudil to suppress VM via blocking ROCK2,all of which were simultaneously encapsulated in the same NPs(Figure 1).