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This study investigated the neuroprotective activity of red ginseng extract (RGE, Panax ginseng, C.A.Meyer) against kainic acid (KA)-induced excitotoxicity in vitro and in vivo.Oral administration of RGE (30 and 200 mg/kg) in mice decreased the MDA level induced by KA injection (30 mg/kg, i.p.).In hippocampal cells,RGE inhibited KA-induced excitotoxicity in a dose-dependent manner as measured by the MTr assay.