含噻唑海洋环肽Venturamide B的全合成研究

来源 :中国化学会第30届学术年会 | 被引量 : 0次 | 上传用户：urtracy2009

【摘要】

：

随着疟原虫对一线抗疟药物耐药性的不断增强,人类对新型抗疟疾药物需求也变得越来越迫切.1Venturamides A-B是2007年从海洋蓝藻(Oscillatoria sp.)中分离得到的一类具有良好抗疟疾活性的含噻唑海洋环肽类化合物2,其对恶性疟原虫(P.falciparum)的IC50值分别可以达到8.2 μM和5.2 μM.近来,我们小组以市售氮末端保护的氨基酸为原料,简洁高效地制备得到噻/

【作者】

：

刘义张翔宇蒋柱峰苏继基杜宇国

【机构】

：

烟台大学,山东省烟台市莱山区清泉路30号,264005 中国科学院生态环境研究中心,100085,

【出处】

：

中国化学会第30届学术年会

【发表日期】

：

2016年7期

【关键词】

：

噻唑海洋环肽 Venturamide B 全合成

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含噻唑海洋环肽Venturamide B的全合成研究

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