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Objective To detect the lipid levels in patients with cardiovascular disease,and to analyze its relationship with cardiovascular disease risk correlation.Methods Totally 210 cases of first cardiovascular disease were in the observation group and 150 cases of healthy adults were in the control group.Fasting blood taken with automatic biochemical detector for detecting total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 and apolipoprotein B and the other lipid parameters.Result TC, TG, LDL-C and apolipoprotein B of patients in observation group were (6.1±-0.3), (1.9±0.8), (3.9±1.5), (1.4±0.7) mmol/L, there were (4.4±0.6), (1.1±0.5), (2.6±0.9), (0.9±0.3) mmol/L in the control group, these values in observation group were higher than that of the control group (P<0.05), while apolipoprotein A1 of the observation group was (1.5±0.3) mmol/L, which was significantly lower compared with the control group (1.9±0.2) mmol/L (P<0.05); body mass index and HDL-C in the two groups were not statistically significant (P>0.05).210 cases of patients in observation group were divided into very high-risk group (50 cases), high-risk group (44 cases), risk group (64 cases) and low-risk group (52 cases).TC, TG, LDL-C and apolipoprotein B levels and the risk of cardiovascular disease were significantly grading positive correlation (r=0.786、 0.753、 0.663、 0.900, all P<0.05), apolipoprotein A1 and cardiovascular disease risk classification showed a significant negative correlation (r=-0.691, P<0.05).Conclusions For patients with the first episode of cardiovascular disease, combined detection of these serum lipids can be an important way as a predictor of cardiovascular events.