With the advent of the next chapter of nanotechnology (―Nano 2‖) in the USA, there is an expectation to get more nanomaterials and nano-enabled products to the marketplace, requiring expedited risk assessment and ability to make decisions that can assist assist Nano EHS governance. This necessitates an integrated approach, in which the ability to decide should be premised on expedited testing, grouping and a predictive approaches towards nanomaterial safety that addresses material categories instead of relying on individual materials only.