【摘 要】
：
Oral vaccines have potential advantages over injected ones to provide effective mucosal and systemic immunity due to their non-invasive nature,lower production costs,as well as higher practicality and
【机 构】
：
NanoAgro Center,Henan Agricultural University,Zhengzhou 450002,China;Department of Sustainable Bioma
【出 处】
：
中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议
论文部分内容阅读
Oral vaccines have potential advantages over injected ones to provide effective mucosal and systemic immunity due to their non-invasive nature,lower production costs,as well as higher practicality and lower cost of administration.Particulate cellulose is a widely used,safe,and inexpensive excipient in oral drug formulations.This research aimed to develop a novel recombinant protein conjugate for oral vaccine formulations consisting of crystalline particulate cellulose as a carrier and a combination of recombinant antigens,adjuvants,and targeting agents for the inductive sites of the mucosal immune system,attached to the carrier via the cellulose binding domain,i.e.the amino acid sequence of cellulolytic enzymes responsible for adhesion of the enzyme to the cellulose surface (Fig.1).
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