弥漫大B细胞淋巴瘤HDAC3-STAT3通路抑制作用的研究进展

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户:lingshao2009
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  血系统肿瘤中,信号传导与转录激活因子3(Signal transducer and activator of transcription 3,STAT3)通路活化后致瘤作用已在多发性骨髓瘤、霍奇金淋巴瘤中多有报道。在DLBCL中,有实验证实STAT3活化主要存在于ABC亚型中,STAT3活化后导致下游与细胞增殖、凋亡相关基因的异常表达。
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