【摘 要】
:
A rapid and sensitive UPLC/Q-TOF-MS method has been established for analysis of the constituents in rat serum after oral administration of Fufang Zhenzhu TiaoZhi (FTZ) capsule,an effective compound pr
【机 构】
:
Key Unit of Modulating Liver to Treat Hyperlipemia SATCM (State Administration of Traditional Chines
论文部分内容阅读
A rapid and sensitive UPLC/Q-TOF-MS method has been established for analysis of the constituents in rat serum after oral administration of Fufang Zhenzhu TiaoZhi (FTZ) capsule,an effective compound prescription for treating hyperlipidemia in clinic.The UPLC/MS information of samples was obtained first in FTZ preparation and FTZ-treated rat serum.Mass spectra were acquired in both negative and positive ion modes.36 constituents in rat serum after oral administration of FTZ were detected,including the alkaloids,ginsenosides,pentacyclic triterpenes and their metabolites.These chemicals were identified based on the retention time and mass spectrometry data with those of authentic standards or comparison of the literattres reports.27 prototype components originated from FTZ and 9 were the metabolites of the constituents from FTZ.These results shed a light on the potential active constituents of the complex traditional Chinese medicinal formula.
其他文献
Transcriptional coactivator PPARγ coactivator-1α (PGC-1α) and corepressor receptor-interacting protein 140 (RIP140) are opposing-functional regulators in maintaining energy balance of most metabolic t
目的:探讨神经肽Y(NPY)和五羟色胺对腹泻型肠易激综合征(D-IBS)发病机制的影响,为从脑肠轴方面分析研究腹泻型肠易激综合征的发生机制提供理论依据.方法:采用母乳分离+醋酸刺激+四肢束缚制作腹泻型肠易激综合征大鼠模型,通过免疫组化法检测大鼠结肠组织中五羟色胺(5-HT)的蛋白表达水平,采用实时荧光定量RT-PCR检测大鼠下丘脑和结肠组织中NPYmRNA的表达.结果:与正常组相比,NPY mRN
目的:用不同浓度三七总皂苷(panax notoginseng saponin,PNS)和卡维地洛干预急性心肌梗死(acute myocardial infarction,AMI)大鼠,评价其改善心功能作用的疗效.方法:建立大鼠AMI模型84只,随机分为心肌梗死对照组(AMI组),三七总皂苷治疗低(PNS-L,20mg.kg-1·d-1)、中(PNS-M,40 mg.kg-1·d-1)、高(PNS
Hyperlipidemia has been thought to be a modifiable risk of coronary heart disease (CHD),and the patients generally require a chronic medication and a diet or lifestyle regulation to manage their hyper
目的:研究蟛蜞菊内酯对脂多糖(lipopolysaccharide,LPS)诱导RAW264.7细胞COX-2、NO及TNF-α的作用.方法:ELISA方法检测0.2、2、20μmol·L-1不同浓度蟛蜞菊内酯对终浓度为10μg·mL-1LPS诱导RAW264.7细胞产生TNF-α,NO及PGE2的影响,Western blot方法检测蟛蜞菊内酯对LPS诱导COX-2酶蛋白表达的影响.结果:LPS
目的:评价用径向基(RBF)神经网络所建立的预测利培酮稳态血药浓度模型的预测性能.方法:将数据分为训练集、校验集和测试集来建立获取输出变量与输出变量两者间关系的RBF网络模型,其中以患者的性别、年龄、体重、剂量、血压、多项生理生化指标等37项参数为输入变量,利培酮稳态血药浓度为输出变量.用训练集和校验集的网络计算输出值与目标输出值之间的均方差(MSE)和相关系数(R)来综合评价网络模型的学习效果,
The deposition of amyloid β-protein (Aβ) fibrils into plaques within the brain parenchyma and along cerebral blood vessels is a hallmark of Alzheimers disease (AD).Aβ42 oligomers and fibrils cause the
Aims-To further investigate the anti-colorectal carcinoma (CRC) effect of Sophoridine (SRI) which is a quinolizidine alkaloid extracted from a traditional Chinese medicine (TCM) Sophora alopecuroides
Sulfation and glucuronidation are the principal metabolic pathways of flavonoids,and extensive phase Ⅱ metabolism is the main reason for their poor bioavailabilities.The purpose of this study was to c
目的:研究造血干细胞移植术后环孢素A(Cyclosporin A,CsA)血药浓度与各生化指标以及合并使用药物的相关性.方法:记录本院造血干细胞移植术后静脉注射CsA和口服CsA患者血药浓度值、相应生化检验值及喹诺酮类抗菌药、三唑类抗真菌药、护肝类药物、糖皮质激素类药物、质子泵抑制剂、胃肠动力药物的使用等数据,应用SPSS统计软件对数据进行线性回归分析.结果:静脉注射CsA单位剂量血药浓度与总胆红