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目的探讨高血压患者动态动脉僵硬指数(AASI)与血压变异性(BPV)的关系。方法入选2009-03-2011-10中国医科大学附属第一医院就诊的高血压患者119例,所有患者均行24h动态血压监测。AASI定义为1减去24h舒张压和收缩压的回归系数。依据AASI水平,分为4组:AASI<0.30、0.30～<0.41、0.41～<0.52、≥0.52。结果相关性分析显示,AASI分别与年龄(r=0.301,P<0.01)、24h收缩压(r=0.276,P=0.001)、白昼收缩压(r=0.225,P=0.008)、夜间收缩压(r=0.366,P<0.01)、24h脉压(r=0.510,P<0.01)、24h收缩压标准差(r=0.297,P=0.001)呈正相关,而与24h舒张压标准差(r=-0.256,P=0.002)、24h平均心率标准差(r=-0.205,P=0.017)及24h平均动脉压标准差(r=-0.202,P=0.017)呈负相关。多元线性逐步回归分析显示,AASI与24h脉压和24h收缩压标准差呈正相关(β=0.321,β=0.725,均P<0.01),与24h舒张压标准差和24h平均动脉压标准差呈负相关(β=-0.428,β=-0.346,均P<0.01)。结论 AASI与BPV密切相关。
Objective To investigate the relationship between dynamic arterial stiffness index (AASI) and blood pressure variability (BPV) in patients with essential hypertension. Methods All patients were enrolled in the First Affiliated Hospital of China Medical University during 2009-03-2011-10. All patients underwent ambulatory blood pressure monitoring for 24 hours. AASI is defined as the regression coefficient of 1 minus the 24h diastolic and systolic blood pressure. According to the level of AASI, divided into 4 groups: AASI <0.30,0.30 ~ <0.41,0.41 ~ <0.52, ≥0.52. Results Correlation analysis showed that AASI was significantly associated with age (r = 0.301, P <0.01), systolic blood pressure at 24h (r = 0.276, P = 0.001), systolic blood pressure at daytime (r = 0.366, P <0.01), 24h systolic pressure standard deviation (r = 0.297, P = 0.001) 0.256, P = 0.002), standard deviation of 24h mean heart rate (r = -0.205, P = 0.017) and standard deviation of 24h mean arterial pressure (r = -0.202, P = 0.017). Multivariate linear stepwise regression analysis showed that AASI was positively correlated with 24h standard pressure and 24h systolic pressure standard deviation (β = 0.321, β = 0.725, both P <0.01), with 24 h diastolic standard deviation and 24 h mean arterial pressure standard deviation (Β = -0.428, β = -0.346, all P <0.01). Conclusion AASI is closely related to BPV.