A signaling cascade of epidermal growth factor receptors( EGFR),plays a key role in regulating cell proliferation and differentiation in many tissue types.
1,2,3-三氮唑及其代表的"点击化学"广泛应用于药物设计、材料科学和生物正交反应1.1,2,3-三氮唑具有独特的五员氮杂环芳香结构,因此,我们关注于利用1,2,3-三氮唑作为的药效团的研究2,3.
近年来,致病微生物传播事件频频发生引起了人们对抗菌试剂越来越多的关注.季铵盐是一类活性持久的阳离子型抗菌剂,但长期大量使用易造成环境二次污染并可使微生物产生耐药性.
Transition-metal catalyzed arylation on an unactivated C-H bond has become a much concerned field recently since this strategy could provide useful aromatic compounds straightforwardly with good atom-
Quinolizine derivatives are presented in a large number of alkaloids[1].
Our initial work began with a study of transformation of enaminones and propynone toward heterocycles.
Sodium sulfinates have recently been demonstrated as electrophilic partners in transition-metal-catalyzed desulfitative C-C cross-coupling reactions,in organic synthesis.
Azatrienes constitute important synthetic blocks for the six-membered aza-heterocycles.
Lactone marasmane sesquiterpenes(such as Ⅰ,Ⅱ and Ⅲ shown in scheme 1A) were isolated from the fruiting bodies of Russula foetens widely distributed in China.
Water was used as promoting medium for three-component reactions of alkylglyoxals,1,3-dicarbonyl compounds and a nucleophile,which produces 1,4-diketone scaffolds in a straightforward way.