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Parkinsons disease (PD)-like symptoms can be provoked by administration of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP).Whereas the neurotoxic effects within several days after MPTP administration on dopaminergic neurons in nucleus accumbens and striatum have been widely investigated, the research of the modulation of hippocampal synaptic transmission in response to acute MPTP application remains open.Data are presented showing that bath-application of MPTP mediates a short-term enhancement of AMPA and NMDA receptor-mediated field excitatory postsynaptic potentials (fEPSPs) followed by a decrease to or below baseline level in a concentration dependent manner (50-100 μM).The MPTP mediated effect on fEPSP was antagonized by a dopamine D2 receptor antagonist.A tyrosine phosphatase inhibitor facilitated MPTP-induced fEPSP depression, but a tyrosine kinase inhibitor attenuated the MPTP effect.The tyrosine phosphatase dependent DHPG mediated fEPSP depression was attenuated by previous application of MPTP, whereas a DHPG-induced depression of synaptic transmission facilitated the MPTP mediated attenuation of fEPSPs.We conclude that acutely applied MPTP affects basal synaptic transmission under the involvement of D2 receptors and enhancement of protein tyrosine phosphorylation.