Kernel machine association testing for longitudinally-measured quantitative phenotypes

来源 :上海交通大学 | 被引量 : 0次 | 上传用户:wyx8113999
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Recent developments in high-throughput sequencing technologies have made it possible to search for both rare and common genetic variants associated with complex diseases.
其他文献
泉港是新兴的港口石化城,国家级循环经济示范园区和省级石化生态工业示范园区,加强环境保护,建设生态文明备受社会高度关注.当前,我国生态安全问题已成为社会各界广泛关注的焦点,首先是水环境形势严峻,二是大气污染问题,三是生物多样性受到严重威胁.对策建议:1.坚持观念先行,强化全社会生态文明意识;2.切实转变经济发展方式;3.实行严格的环境资源保护制度.
目的:探讨急诊状态下微创颅内血肿碎吸术(MPST)对于幕上出血量30~50mL高血压脑出血(HICH)患者,尤其是已经有脑疝先兆和已经出现脑疝病人的抢救治疗,为后续治疗争取更多的时间和机会。方法:31例幕上出血量在30~50 mLHICH患者,均在急诊科行紧急状态微创血肿穿刺引流术,然后送病房常规治疗,观察在血肿排除、吸收时间、再出血率、有效率、生活能力、神经功能缺损评定和住院费用等方面的疗效。结
目的:浅谈腹腔穿刺术在诊断闭合性腹腔脏器损伤中的重要性和实用性。方法:按常规进行腹腔穿刺术,但一次穿刺阴性并不能排除腹腔脏器的损伤,必要可重复或多部位穿刺。结果:经手术治疗证实总阳性率达100%,准确率达98%。结论:腹腔穿刺术在诊断闭合性腹腔脏器损伤中简便易行,并发症少,阳性率高,实用于基层推广。
Serial correlation in the residuals of time series models can cause bias in both model estimation and prediction.
We propose a method of constructing simultaneous confidence intervals of a vector of location parameters from stochastic approximation.
Within-subject dependence is a characteristic of longitudinal clinical trials,but accurate modeling of this dependence is not always straightforward when faced with the many choices of marginal and co
We consider a class of vector autoregressive models with banded coefficient matrices.The setting represents a type of sparse structure for high-dimensional time series,though the implied au-tocovarian
Estimating equations are a popular avenue for creating point estimates.Fisher dared to also obtain a distributional inference by solving a system of structural equations.
In spite of the recent surge of interest in quantile regression,joint estimation of linear quantile planes remains a great challenge in statistics and econometrics.
Precision medicine is a medical paradigm that focuses on finding the most e ective treatment decision based on individual patient information.