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  5. Cellular repressor of E1A stimulated genes antagonizes inflammation of macrophages through lysosome

Cellular repressor of E1A stimulated genes antagonizes inflammation of macrophages through lysosome

来源 :第十二届中国介入心脏病学大会(CIT2014) | 被引量 : 0次 | 上传用户：emeng
【摘 要】
：
Background Atherosclerosis is a vascular inflammatory disease,which leads to complications that cause myocardial infarction and stroke.Macrophages play crucial roles in atherosclerotic immune response
【作 者】
：
Sun Mingyu Yan Chenghui Tian Xiaoxiang Li Yang Tao Jie Han Yaling 
【机 构】
：
Department of Cardiology,Institute of Cardiovascular Research of People's Liberation Army,Shenyang
【出 处】
：
第十二届中国介入心脏病学大会(CIT2014)
【发表日期】
：
2014年3期
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Background Atherosclerosis is a vascular inflammatory disease,which leads to complications that cause myocardial infarction and stroke.Macrophages play crucial roles in atherosclerotic immune responses.Cellular repressor of E1A-stimulated genes (CREG) is a secretory glycoprotein implicated in cellular growth and differentiation.CREG has been found to antagonizes TNF-α-induced inflammation of vascular endothelial cells.Immunolocalization of endogenous CREG confirmed that intracellular CREG is localized in lysosomes.The aim of this study was to investigate the anti-inflammation effects of CREG on macrophage and the participation of lysosome in the process.
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