It is already more than 10 years after the completion of Human Genome Project.However, the mechanism about how genomic information guides the gene expression in a particular space and time remains to be elucidated."Structure determines function" is a consensus that we understand the laws of nature.In biology, this consensus is not only applicable to RNA, protein and other small-scale molecules;the same should also apply to macromolecules such as the entire DNA composition of whole genome.