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Relieving pulmonary edema is the key of a successful treatment to seawater drowning.Sodium tanshinone ⅡA sulphonate (STS) ,one of the main active components from Chinese herb Danshen, is observed to reduce lung edema and protect lung from LPS-induced acute injury.In the study we investigated whether STS treatment attenuates seawater aspiration-induced acute pulmonary edema, and examined the effects of Na-K-ATPase in it.