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Objectives Quality of life (QoL) is an important outcome in hemophilia studies and clinical trials,however,little is known about the QoL of boys with hemophilia A (HA) in China.We report the QoL outcome of boys with severe HA in China,enrolled in a recombinant factor Ⅷ (Kogenate(R)) clinical trial comparing the efficacy of prophylaxis to on demand therapy.