【摘 要】
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Caspases are a family of cysteinyl aspartate proteinases known for their essential roles in the regulation of apoptosis.To date,about 20 caspases have been
【机 构】
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State Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology,Southw
【出 处】
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中国遗传学会第九次全国会员代表大会暨学术研讨会
论文部分内容阅读
Caspases are a family of cysteinyl aspartate proteinases known for their essential roles in the regulation of apoptosis.To date,about 20 caspases have been identified although,few have been cloned and characterized in Bombyx mori.Two caspase-9 variants from the B.mori embryonic cell line (BmE),designated BmDroncL and BmDroncS were cloned.BmDroncL has three classic domains: a caspase recruitment domain (CARD) and large/small subunits,and is a homologue of Drosophila Dronc,human caspase-9,Aedes Dronc and fish caspase-9,while BmDroncS lacks the large subunit.Instantaneous expression of BmDroncL caused typical apoptosis in Sf-9 cells.Moreover,BmDronc gene expression increased markedly during the silkworm metamorphosis at the larva-pupa and pupa-moth stages,which suggested that BmDronc plays a crucial role during B.mori metamorphosis.
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