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Background:This research aims to investigate the correlation between lethal thrombus formation and three risk factors including gender,fracture position and thrombus source.Methods: The study reviewed 144 cases of deep venous thrombosis after lower limb fracture who were implanted with temporary inferior vena cava filter or retrievable filter.They were classified aslethalor nonlethal based on the size of thrombus measuredby the digital subtraction angiography(DSA).The thrombus greater than 10mm in diameter andthe diffuse multiplethrombi were considered as lethal.The thrombus less than 10mm in diameter and the invisible thrombus were non-lethal.All patients were classified into different groups according to the gender,fracture position and the site of thrombus formation.The x2-test and logistic linear regression analysis were performed todetermine the correlation between the three risk factors and lethal thrombus formation.Results:There was no statistical difference between the male group and the female group,amongthe groups with different fracture positions or among the groups with different thrombus source.The single fracture in lower limb and multiple fractures had similar potential to induce lethal thrombus.The logistic linear regression suggested that the incidence rate of lethal thrombus in the group of above the popliteal veinwas lower than the other three groups(P < 0.05).Conclusion: Compared with the thrombus formulated above the popliteal vein,the thrombus formulated in or below the popliteal vein and the multiple thrombi seems easier to induce lethal thrombus.It should be paid more attention in clinical practice.