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[目的]探讨乙肝病毒C基因分型与肝硬化的关系。[方法]利用基因芯片方法对112例乙肝患者进行基因分析,其中CHB73例,CHG3例,LC26例,AHB5例,HCC5例,肝纤维化指标用放射免疫方法测定。[结果]B基因型30例(26.8%),C基因型79例(70.5%),B/C混合型3例(2.7%),未发现A、D、E、F、G、H及其混合型。在CHB与LC患者中,C基因型的检出率明显高于B基因型,差异有统计学意义。C型与B型的血清4项纤维指标:透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(ⅣC),C型均高于B型,测定结果有统计学差异。[结论]C基因型在慢性乙型肝炎(CHB),肝硬化(LC)中占优势,与肝病的严重性有关。
[Objective] To investigate the relationship between hepatitis C virus C genotyping and cirrhosis. [Methods] The gene chips were used to analyze 112 cases of hepatitis B patients, including 73 CHB cases, 3 CHG cases, 26 LC cases, 5 AHB cases and 5 HCC cases. The indexes of liver fibrosis were determined by radioimmunoassay. [Results] There were 30 cases (26.8%) of B genotype, 79 cases (70.5%) of C genotype and 3 cases (2.7%) of B / C mixed type. No A, D, E, F, G, Hybrid. In CHB and LC patients, the detection rate of genotype C was significantly higher than genotype B, the difference was statistically significant. Four kinds of fiber indexes of type C and type B were higher than that of type B in hyaluronic acid (HA), laminin (LN), type Ⅲ procollagen (Ⅲ), type Ⅳ collagen (ⅣC) The results are statistically different. [Conclusion] C genotype predominates in chronic hepatitis B (CHB) and liver cirrhosis (LC), and is related to the severity of liver disease.