【摘 要】
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The overuse of antibiotics in the clinical setting has resulted in a large amounts of drug-resistant bacteria emerging.These bacteria often express metallo-β-lactamases (MβLs), which hydrolyze the β-l
【机 构】
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Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education,Colle
论文部分内容阅读
The overuse of antibiotics in the clinical setting has resulted in a large amounts of drug-resistant bacteria emerging.These bacteria often express metallo-β-lactamases (MβLs), which hydrolyze the β-lactam ring of β-1actam-containing antibiotics, so drug-resistant bacteria could inactivate almost all β-1actam antibiotics including penicillins, cephalosporins and carbapenems[1,2].
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β-Lactam antibiotics, such as penicillins, cephalosporins, and carbapenems, have long been diffusely and successfully used in treating bacterial infections [1].
At the present time, the frightening threat of β-1actamase with multidrug resistance acquirement to the β-1actam antibiotics constitutes a serious public health threat.Although commercialized inhibito
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