【摘 要】
：
目的 比较老年抑郁障碍、遗忘型轻度认知功能损害与正常对照的全脑灰质体积的变化.方法 入组老年抑郁障碍(LDD)患者24例、aMCI患者26例,正常对照34例,完成头颅核磁共振扫描,应用基于体素的形态学测量法(VBM)比较灰质体积差异.结果 LDD组与NC组比较左侧中央后回、左侧中央前回、左侧顶上小叶、左侧顶叶以及双侧额叶等脑区的灰质体积萎缩,差异有显著统计学意义(P＜0.001,uncorrect
【出 处】
：
长三角地区神经科学论坛暨浙江省神经科学学会2014年年会
论文部分内容阅读
目的 比较老年抑郁障碍、遗忘型轻度认知功能损害与正常对照的全脑灰质体积的变化.方法 入组老年抑郁障碍(LDD)患者24例、aMCI患者26例,正常对照34例,完成头颅核磁共振扫描,应用基于体素的形态学测量法(VBM)比较灰质体积差异.结果 LDD组与NC组比较左侧中央后回、左侧中央前回、左侧顶上小叶、左侧顶叶以及双侧额叶等脑区的灰质体积萎缩,差异有显著统计学意义(P＜0.001,uncorrected,K≥30体素).aMCI组与NC组比较左侧颞中回、左侧额下回,右侧额中回、右侧中央前回、右侧岛叶、右侧海马及双侧颞上回、双侧海马旁回等脑区的灰质体积萎缩,差异有统计学意义(P＜0.001,uncorrected,K≥30体素).aMCI组在左侧豆状核、左侧颞叶、左侧顶叶以及右侧顶叶、右侧楔前叶、右侧顶下小叶、右侧顶上小叶、右侧岛叶、右侧颞上回等脑区的灰质体积低于LDD组(P＜0.001,uncorrected,K≥30体素).结论 老年抑郁障患者脑部灰质萎缩区域集中在双侧额叶、左侧顶叶,aMCI脑区灰质萎缩区域累及范围更加广泛.
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